23 drug efflux one of the most studied mechanisms of cancer drug resistance involves reducing drug accumulation by enhancing efflux members of the atp binding cassette abc transporter family proteins enable this efflux and are important well studied regulators at the plasma membranes of healthy cells. One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells this is a very serious problem that may lead to recurrence of disease or even death this section is intended to introduce some of the main ways in which cancer cells can resist treatments. Biophysicists at ruhr universitat bochum rub have demonstrated that raman microscopy can be used to detect the resistance of tumour cells to cancer drugs unlike conventional approaches this . However the treatment will frequently stop working as the cancer cells become tamoxifen resistant the development of resistance to endocrine therapy and metastatic progression are leading
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