Discover nonlinear ultrasound contrast agent imaging quantify relative perfusion and study biomarker expression with ease microbubble contrast agents have been used in ultrasound imaging as a means of improving the visualization of blood flow with respect to the surrounding tissue. Contrast enhanced ultrasound ceus is the application of ultrasound contrast medium to traditional medical sonography ultrasound contrast agents rely on the different ways in which sound waves are reflected from interfaces between substances this may be the surface of a small air bubble or a more complex structure. With minor exceptions contrast agents for ultrasound are microbubbles 1 7 um in diameter they are new class of agents that are mainly used as intravascular contrast media though they can also be instilled into the urinary bladder to look for ureteric reflux and into the uterus to check tubal patency microbubbles do not diffuse out of the circulation and thus behave as blood pool markers. Contrast enhanced ultrasound ceus involves the administration of intravenous contrast agents containing microbubbles of perfluorocarbon or nitrogen gas the bubbles greatly affect ultrasound backscatter and increase vascular contrast in a similar manner to intravenous contrast agents used in ct and mri 1 examples of ultrasound contrast agents available commercially include sonovue bracco. The engineering of ultrasound contrast agents co optimized with systems for imaging their local distribution and enhancing their use in local drug delivery is a rich multidisciplinary undertaking ultrasound contrast agents are small gas bubbles encapsulated by a stabilizing shell with a typical diameter on the order of microns table 1
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